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There has recently been significant discussion in clinical circles about the appropriateness of the ketogenic diet for the treatment of ovarian cancer. There is, as with most cancer forms and their most appropriate dietary treatment, vociferous debate between advocates of low-carbohydrate and ketogenic diets, and those more inclined towards higher-carbohydrate approaches. There is also a lot of complexity due to the very diverse nature of cancers and cancer cells, even within an individual. Tumours of the abdomen, including ovarian cancer, are characterised by widespread and rapid metastases in the peritoneal cavity. It has been demonstrated that adipocytes fat cells of the omentum promote migration and invasion by ovarian cancer cells and that these processes are mediated by inflammatory adipokines including interleukin-8 IL It is thought that this occurs due to upregulation of adipocyte Protein 2 a fatty-acid carrier protein in omental metastases compared to primary ovarian tumours. These findings taken together, suggest that ovarian cancer cells, when migrated to areas with a relative abundance of adipocytes like the omentum can induce adipose tissue to release fatty-acids and that this can be used efficiently as a fuel.
September 19, Women with ovarian or endometrial cancer who followed the ketogenic diet for 12 weeks lost more body fat and had lower insulin levels compared to those who followed the low-fat diet recommended by the American Cancer Society, according to a new study published by researchers at the University of Alabama at Birmingham. Researchers studied 45 overweight or obese women with ovarian or endometrial cancer. The participants were not actively attempting to lose weight and were not on special diets at the time of enrollment. Each was randomly assigned to either the ketogenic diet or the American Cancer Society-recommended diet. Researchers decided to focus on women with ovarian and endometrial cancers based on the cancers’ health outcomes and risk factors. The ketogenic diet was used because it limits the number of carbohydrate foods that are consumed, foods that increase glucose and insulin.
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