Author contributions: All authors substantially contributed to conception and writing of manuscript. This approach is used in clinical conditions as the ketogenic diet. The ketogenic diet is actually a biochemical model of fasting. It includes replacing carbohydrates by fats in daily meal. The ketogenic diet can be used to treat clinical conditions, primarily epilepsy. Sometimes they can be toxic for the brain. Ketoacidosis which is a very dangerous complication of diabetes mellitus or alcoholism can be taken as an example. Glucose is taken up by astrocytes which metabolize it into lactate. Monocarboxylates are metabolized directly in Krebs cycle in mitochondria, therefore, they can be considered as non-glycolytic energy substrates. The ketogenic diet is based on this approach and may be used to treat clinical conditions Gano et al.
On discharge, June. Furthermore, in the case of ketogenic diet, the level of acetone in the brain appeared to be lower than in experiments where antiepileptic action was demonstrated McNally and Hartman, Overkamp, R. Ketoacidosis in a non-diabetic woman who was fasting during lactation [ 22 ]. New aspects of ketone bodies in energy metabolism of dairy cows: a review. In previous cases of ketoacidosis, in lactating non-diabetic women as well as in other non-diabetic patients, physiological stressors such as fasting, infections, lactating twins and recently even bariatric surgery have been considered to be the push factor into ketoacidosis [ 9 — 14 ]. She avoided nuts or shellfish but would have tablespoons of peanut butter per day. The expression of MCT in rats is variable increasing during starvation or in a ketogenic diet and decreasing with age Leino et al. Metabolism portal. No genetic testing of any kind was performed. Other conditions: There is emerging evidence for the use of ketosis in other conditions such as type 1 diabetes, non-alcoholic fatty liver disease, acne, polycystic kidney disease and polycystic ovary syndrome, although evidence quality is limited by small sample sizes. However, to the best of our knowledge this is the first reported case in the literature of ketoacidosis in a non-diabetic patient, associated with a combination of low carbohydrate, high fat diet and lactation.
Although ketogenic diet is safe in nonpregnant individuals, its safety in lactating mothers is unknown. Cancer: Preclinical studies have indicated ketosis may have anti-tumor effects, although clinical trials have been limited by small sample sizes and have not shown conclusive benefit. Sweden: Mat vid Diabetes; It revealed pH 7. This utilization of oxaloacetate in gluconeogenesis can make it unavailable to condense with acetyl-CoA, preventing entrance into the TCA cycle. It is a great challenge for medical services to be updated and to give proper information to our community. Lactation ketoacidosis is well described in postpartum lactating cattle in the veterinary literature [ 2 ]. SGLT2 inhibitor medications have been associated with cases of euglycemic ketoacidosis – a rare state of high ketones causing a metabolic acidosis with normal blood glucose levels. Written informed consent was obtained from the patient for publication of this case report.
Revised 25 Apr This process involves the conversion of fats by the liver into fatty acids thus producing ketone bodies. Alcoholic ketoacidosis.