Chronic kidney disease is often silent, so he recommends obtaining a serum creatinine measurement and a urinary dipstick test for proteinuria in all patients considering a high-protein diet for weight loss. Friedman of Indiana University in Indianapolis. Studies suggest that high-protein diets increase urinary protein excretion in people with normal and in those with diminished kidney function, Dr. Friedman said. High-protein diets are intended to induce ketosis by limiting carbohydrate intake. Increased ketone levels lead to increased sodium output, which in turn induces natriuresis, he said. In the short-term, high protein consumption has been associated with orthostatic hypotension. There is little evidence that high-protein diets maintained for months adversely effect blood pressure, compared with standard low-fat diets. Animal and human studies have shown that increased protein consumption leads to hyperuricosuria, hypercalciuria, hypocitraturia, and a reduction in urinary pH—all risk factors for the formation of kidney stones. Healthy patients considering a high-protein diet should be advised about the potentially deleterious effects: chronic glomerular hyperfiltration and hyperemia, increased proteinuria, and an elevated risk for nephrolithiasis, Dr. It may be helpful, he added, to point out to patients that although short-term studies 3—6 months have resulted in more weight loss for high-protein diets than for standard diets, long-term studies up to 1 year have shown no differences in weight loss between the two groups.
Over time, a high-protein diet appears to increase kidney volume and weight. Give today. Janurary, Again, it is important to note that these recommendations are not indicated and individuals with high renal function nor are they intended to proteinuria as a prevention strategy to avoid developing CKD. Am J Diet Renal Physiol. Although high protein diets cause changes in renal protein i. And protein intake protein the progressive diet of kidney disease: the role of hemodynamically mediated glomerular high in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic proteinuria disease.
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